Laboratorium Bioinformatyki i Biologii Systemów

Badania prowadzone w Laboratorium Bioinformatyki i Biologii Systemów mają charakter interdyscyplinarny z pogranicza biologii, chemii, fizyki oraz matematyki. Badania te mają na celu zarówno rozwijanie nowych narzędzi bioinformatycznych, jak i ich zastosowanie w połączeniu z metodami współczesnej biologii molekularnej do badania struktury, funkcji i ewolucji białek oraz ich oddziaływań z ligandami, ze szczególnym uwzględnieniem istotnych procesów biologicznych takich jak metylacja i metabolizm kwasów nukleinowych.

Obszarem zainteresowań zespołu LBBS są również badania genomów, transkryptomów i metagenomów prowadzone z wykorzystaniem sekwencjonowania nowej generacji w oparciu o system Illumina.

dr hab. Krzysztof Ginalski , Prof. UW
e-mail: k.ginalski@cent.uw.edu.pl
telefon: +48 22 55 40833
pokój: 2151 (II siedziba)


Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease
Wezyk, M., Szybinska, A., Wojsiat, J., Szczerba, M., Day, K., Ronnholm, H., ... & Ilkowski, J. (2018).
Journal of Alzheimer's Disease, 62(1), 175-202.
Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution
Mourad, R., Ginalski, K., Legube, G., & Cuvier, O. (2018).
Genome biology, 19(1), 34
Hypermethylation of TRIM59 and KLF14 influences cell death signaling in familial Alzheimer’s disease
Wezyk, M., Spólnicka, M., Pośpiech, E., Pepłońska, B., Zbieć-Piekarska, R., Ilkowski, J., ... & Skrzypczak, M. (2018).
Oxidative medicine and cellular longevity, 2018
PDBsum: Structural summaries of PDB entries
Laskowski, R. A., Jabłońska, J., Pravda, L., Vařeková, R. S., & Thornton, J. M. (2018).
Protein Science, 27(1), 129-134
Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies
Kutner, J., Shabalin, I. G., Matelska, D., Handing, K. B., Gasiorowska, O., Sroka, P., ... & Minor, W. (2018).
Biochemistry, 57(6), 963-977.
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.
F. Aymard, M. Aguirrebengoa, E. Guillou, B.M. Javierre, B. Bugler, C. Arnould, V. Rocher, J.S. Iacovoni, A. Biernacka, M. Skrzypczak, K. Ginalski, M. Rowicka, P. Fraser, G. Legube
Nature Structural & Molecular Biology 24, 353-361
Comprehensive classification of the PIN domain-like superfamily.
Matelska, D., Steczkiewicz, K., & Ginalski, K.
Nucleic Acids Research 45, 6995-7020
A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase.
Kulecka, M., Wierzbicka, A., Paziewska, A., Mikula, M., Habior, A., Janczyk, W., ... & Czlonkowska, A.
Journal of Hepatology
Fungal lifestyle reflected in serine protease reportoire
Muszewska, A., Stepniewska-Dziubinska, M. M., Steczkiewicz, K., Pawlowska, J., Dziedzic, A., & Ginalski, K.
Scientific Reports, 7(1), 9147.
Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.
Shi, W., Vu, T., Boucher, D., Biernacka, A., Nde, J., Pandita, R. K., ... & Jeffery, J. (2017).
Blood, 129(18), 2479-2492.
Phylogeny-based systematization of Arabidopsis proteins with histone H1 globular domain.
Kotliński, M., Knizewski, L., Muszewska, A., Rutowicz, K., Lirski, M., Schmidt, A., ... & Jerzmanowski, A. (2017).
Plant physiology, 174(1), 27-34.
Systematic classification of the His-Me finger superfamily.
Jablonska, J., Matelska, D., Steczkiewicz, K., & Ginalski, K. (2017).
Nucleic acids research, 45(20), 11479-11494.
Cut-and-paste transposons in fungi with diverse lifestyles.
Muszewska, A., Steczkiewicz, K., Stepniewska-Dziubinska, M., & Ginalski, K. (2017).
Genome biology and evolution, 9(12), 3463-3477.
Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing
Fang, D., Lengronne, A., Shi, D., Forey, R., Skrzypczak, M., Ginalski, K., Yan, Ch., Wang, X. Cao, Q, Pasero, P, Lou, H. (2017).
Genes & development, 31(23-24), 2405-2415.
Histone H1 variants in Arabidopsis are subject to numerous post-translational modifications, both conserved and previously unknown in histones, suggesting complex functions of H1 in plants.
Kotliński, M., Rutowicz, K., Kniżewski, Ł., Palusiński, A., Olędzki, J., Fogtman, A., ... & Jerzmanowski, A. (2016).
PloS one, 11(1), e0147908.
Diverse cap-binding properties of Drosophila eIF4E isoforms.
Zuberek, J., Kuchta, K., Hernández, G., Sonenberg, N., & Ginalski, K. (2016).
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1864(10), 1292-1303.
FAM46 proteins are novel eukaryotic non-canonical poly (A) polymerases.
Kuchta, K., Muszewska, A., Knizewski, L., Steczkiewicz, K., Wyrwicz, L. S., Pawlowski, K., ... & Ginalski, K. (2016).
Nucleic acids research 44, no. 8 (2016): 3534-3548.
Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study
Huang, R., Ripstein, Z. A., Augustyniak, R., Lazniewski, M., Ginalski, K., Kay, L. E., & Rubinstein, J. L. (2016).
Proceedings of the National Academy of Sciences, 113(29), E4190-E4199.
Towards engineering novel PE-based immunotoxins by targeting them to the nucleus
Borowiec, M., Gorzkiewicz, M., Grzesik, J., Walczak-Drzewiecka, A., Salkowska, A., Rodakowska, E., ... & Ginalski, K. (2016).
Toxins, 8(11), 321.
Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy
Mikula, M., Skrzypczak, M., Goryca, K., Paczkowska, K., Ledwon, J. K., Statkiewicz, M., ... & Karczmarski, J. (2016).
Nucleic acids research, 44(21), 10150-10164.
A specialized histone H1 variant is required for adaptive responses to complex abiotic stress and related DNA methylation in Arabidopsis
Rutowicz, K., Puzio, M., Halibart-Puzio, J., Lirski, M., Kroteń, M. A., Kotliński, M., Ginalski K., ... & Kościelniak, J.
Plant physiology, pp-00493
Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using Illumina platform
Mitra, A., Skrzypczak, M., Ginalski, K., & Rowicka, M. (2015)
PloS one, 10(4), e0120520
Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding.
Kropiwnicka, A., Kuchta, K., Lukaszewicz, M., Kowalska, J., Jemielity, J., Ginalski, K., ... & Zuberek, J. (2015).
Biochemical and biophysical research communications, 456(1), 47-52.
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.
Yoshida, K., Bacal, J., Desmarais, D., Padioleau, I., Tsaponina, O., Chabes, A., ... & Ginalski, K. (2014).
Molecular cell, 54(4), 691-697.
HarmonyDOCK: the structural analysis of poses in protein-ligand docking.
Plewczynski, D., Philips, A., Grotthuss, M. V., Rychlewski, L., & Ginalski, K. (2014).
Journal of Computational Biology, 21(3), 247-256.
The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification
Majorek, K. A., Dunin-Horkawicz, S., Steczkiewicz, K., Muszewska, A., Nowotny, M., Ginalski, K., & Bujnicki, J. M. (2014).
Nucleic acids research, 42(7), 4160-4179
Probabilistic Approach to Predicting Substrate Specificity of Methyltransferases
Szczepińska, T., Kutner, J., Kopczyński, M., Pawłowski, K., Dziembowski, A., Kudlicki, A., Ginalski K., ... & Rowicka, M. (2014).
PLoS computational biology, 10(3), e1003514.
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing.
Crosetto, N., Mitra, A., Silva, M. J., Bienko, M., Dojer, N., Wang, Q., ... & Pasero, P. (2013).
Nature methods, 10(4), 361.
Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels.
Szczesny, R. J., Hejnowicz, M. S., Steczkiewicz, K., Muszewska, A., Borowski, L. S., Ginalski, K., & Dziembowski, A. (2013).
Nucleic acids research, 41(5), 3144-3161.
DIRS and Ngaro Retrotransposons in Fungi
Muszewska, A., Steczkiewicz, K., & Ginalski, K. (2013)
PLoS one, 8(9), e76319
C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3′ end modification.
Mroczek, S., Krwawicz, J., Kutner, J., Lazniewski, M., Kuciński, I., Ginalski, K., & Dziembowski, A. (2012).
Genes & development, 26(17), 1911-1925.
Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily
Steczkiewicz, K., Muszewska, A., Knizewski, L., Rychlewski, L., & Ginalski, K. (2012)
Nucleic acids research, 40(15), 7016-7045.
Novel AlkB dioxygenases—alternative models for in silico and in vivo studies.
Mielecki, D., Zugaj, D. Ł., Muszewska, A., Piwowarski, J., Chojnacka, A., Mielecki, M., ... & Grzesiuk, E. (2012)
PLoS One 7, no. 1 (2012): e30588
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