Laboratorium Biologii Komórek Glejowych

Do you know that our digestive system has even more cells than our brain? There is an old saying that “We are what we eat”. However, the glial cells in our digestive system has received less attention from the scientific community (for reasons unclear).

Recent studies show that the drugs that are prescribed to Parkinson or Cancer patients can be metabolized in our guts. This adds an extremely new level of complexity in discovering fully functional drugs. This may be one of the major reasons for candidate-drugs that reach yet fail in human clinical trials.

Using in vitro and in vivo models. The main research focus of our group is to understand

  1. How the gut glial cells develop and functions?
  2. How the gut glial cells interact with the metabolites of the food that are consumed.
  3. How the gut glial cells interact with the microbiome?
  4. How the gut glial cells interact with the brain?
  5. How the gut glial cells respond to existing and novel drugs that are usually prescribed to patients?

Highly motivated students at all levels are invited to discuss potential research projects of interest.

PhD Savani Anbalagan
e-mail: s.anbalagan@cent.uw.edu.pl
telefon: +48 22 55 43836
pokój: 02.103

Adres 

Centrum Nowych Technologii (CeNT)
Uniwersytet Warszawski
ul. S. Banacha 2c
02-097 Warszawa

Education and degrees

2014 PhD in Industrial Biotechnology, University of Milano-Bicocca, Milan, Italy

2009 Master of Technology in Industrial Biotechnoloy, SASTRA University, Thanjavur, India

 

Research experience and appointments:

Since July 2019 Assistant Professor (Adiunkt Naukowy) and Head of the Laboratory of Glial biology at CeNT, University of Warsaw.

2015-2019 Senior Postdoc in Prof. Gil Levkowitz group, Weizmann Institute of Science, Rehovot, Israel

2013-2015 Postdoc in Prof. Gil Levkowitz group, Weizmann Institute of Science, Rehovot, Israel

2009-2012 Doctoral student in Prof. Maria Pia Longhese group, University of Milano-Bicocca, Milan, Italy

2009 Guest student at Prof. Daniel Otzen group, University of Aarhus, Aarhus, Denmark

Awards:

2018 Award for outstanding achievements in postdoctoral research, Feinberg Graduate School, Weizmann Institute of Science, Rehovot, Israel

2016 Koshland Prize, Weizmann Institute of Science, Rehovot, Israel

2015-2018 Senior Postdoctoral Fellowship, Weizmann Institute of Science, Rehovot, Israel

2013-2015 Israel PBC Fellowship for Outstanding Post-Doctoral Researchers from China and India

2012 Award for Best project proposal, University of Milano-Bicocca, Milan, Italy

2009-2012 EU-FP7 Marie Curie Early Stage Researcher during PhD studies

2008 Indian Academy of Science – Summer Research Fellowship

 

Key Publications

Anbalagan S*, Blechman J*, Gliksberg M, Gordon L, Rotkopf R, Dadosh T, Shimoni E, Levkowitz G. Synaptic actin dynamics regulates oxytocin neuropeptide content in vivoeLife 2019

Anbalagan S*, Gordon L*, Blechman J, Matsuoka R, Rajamannar P, Wircer E, Biran J, Reuveny E, Leshkowitz D, Stainier D.Y.R, Levkowitz G. Pituicyte cues regulate the development of permeable neuro-vascular interfaces. Dev Cell. 2018

Bonetti D, Anbalagan S, Lucchini G, Clerici M, Longhese MP. Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends. EMBO J. 2013.

Anbalagan S, Bonetti D, Lucchini G, Longhese MP. Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet. 2011.