The Centre of New Technologies invites to a seminar by
Imperial College London
Chemoproteomic methods for studying protein behaviour in cells
Venue: Centre of New Technologies, Banacha 2C, Lecture Hall 0142 (Ground floor)
Chemoproteomic methods for studying protein behaviour
As society moves into the post-genomic era scientists face an extraordinary array of exciting challenges to decipher the emergent properties of the genome at the molecular level. Among the most pressing of these is the need to identify and characterize the interdependence of post-translational modification (PTM) of proteins and their activity that serves to coordinate and control all processes in the cell. A deep spatiotemporal and quantitative understanding of protein modification and enzyme activity in cells is an essential step towards a systems-level model of life, and will be a powerful tool in the increasingly complex search for viable drug targets across all diseases. Indeed, the universal identification, quantification and manipulation of emergent features such as catalytic activity and post-translational modification may fairly be described as a ‘grand challenge’ in contemporary science. The application of chemistry to this challenge is proving particularly powerful and has given rise to a vibrant sub-field broadly termed chemical proteomics. Discussed will be the design and application of chemical probes and reagents for studying protein modifications: N-myristoylation, S-prenylation, O-adenylylation, and more.