Title: One thousand structures of SARS-CoV-2 proteins, or how the Polish Crystallographic Mafia joined the fight against covid-19

Date: 29th April 2021 (Thursday!)

Time: 15:00 pm (Central European Summer Time)

Host: prof. Joanna Trylska

Virtual seminar: https://us02web.zoom.us/j/83926960355

Meeting ID: 839 2696 0355

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Abstract:

The response of the scientific community to the COVID-19 pandemic has been remarkable, with over 1000 structures related to SARS-CoV-2 submitted to the Protein Data Bank by mid-April 2021. With structural data obtained very rapidly by many groups using different techniques and varied experimental approaches, such efforts may lead to inevitable mistakes, errors, and interpretational problems. To help biomedical researchers, who may not be experts in structural biology, navigate through and absorb the flood of structural information, we have created an online resource, covid19.bioreproducibility.org, that aggregates expert-validated information about SARS-CoV-2-related macromolecular models. A number of protein complexes with inhibitors, which are most vital for drug design, were found to pose significant problems. Our critical analysis of a large number of protein structures that are potential or actual targets for drug design, all determined within less than a year using modern experimental tools, is important not only in a current medical emergency but should be also useful as a paradigm study for future projects of high interest to biomedical community.