Opis:
Title of the position: Postdoct in Interdisciplinary Laboratory of Biological Systems Modelling
Scientific discipline: Chemistry/Biophysics/Bioinformatics
Job type: Contract
Number of job offers: 1
Remuneration/Stipend amount/month: 10000
Position starts on: 01.01.2020
Maximum period of contract/stipend agreement: 1 year up to 3 years
Institution: Interdisciplinary Laboratory of Biological Systems Modelling
Project leader: Joanna Sułkowska, associate professor
Project title: Double-knotted proteins – limits of topological complexity of proteins
Project Description: The goal of this project is to develop new methods to apply experimental data from NMR and single molecular manipulation to expand our knowledge of proteins with non-trivial topology. The aim is better understanding of the influence of non-trivial topology on fundamental biological mechanisms such as evolution, function and degradation. The project is interdisciplinary and involves aspects of mathematical knot theory, bioinformatics, computer simulations, biophysics, and both in vivo and in silico studies.br />
Key responsibilities include:
The role of applicant will be to include experimental data into computational study as well as develop new methods. Thus, through the use of multiscale computational methods (combined coarse grain and explicate solvent molecular dynamics/replica exchange), machine learning, co-evolution method we will investigate on one hand the evolution and the conformational stability, and on the other hand we will use state-of-the-art methods to design bio-molecules.
Profile of candidates/requirements:
The successful post-doc candidate will have a PhD degree in physics/chemistry or related discipline, very good experience in conducting molecular modeling, multiscaling modeling, programs such as Modeller, Rosetta. Experience with high-performance computing, knowledge of c++ or Python and scientific computing libraries and Linux environment is necessary. Although not required, any previous experience in investigation of proteins on the single molecule level or interpretation of NMR results and its application to improve the structure based models would be welcome. PhD should be obtained no sooner than 7 years before the starting year of the employment in the project.
Required documents:
Two letters of recommendation, a copy of a PhD certificate (PhD obtained no sooner than 7 years before the starting year of the employment in the project), CV, motivation letter.
We offer:
An opportunity to participate in a multidisciplinary project in one of the best scientific institutions in Poland. Stimulating, young and friendly work environment. Access to high-end computing equipment (CPU clusters). Opportunity to participate in COST network and various EMBO workshops.
Please submit the following documents to: Applications should be submitted by e-mail to Joanna Sułkowska (jsulkowska@cent.uw.edu.pl) no later than 31.12.2019 with the term “Post-doc position in ILBSM” as email’s topic. Following an initial screening of the applications, selected candidates will be contacted by e-mail for further recruitment steps.
- RODO
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Termin nadsyłania aplikacji: 31/12/2019
Słowa kluczowe: proteins with non-trivial topology, nodes, NMR, evolution, knot theory
