Organometallic Chemistry Laboratory

The research work conducted in our laboratory concerns the catalysts for the Ring-Opening Polymerization (ROP) of heterocyclic monomers based on main group metal complexes, as well as the main group metal complexes with N-heterocyclic carbenes (NHCs).

With regard to the former we are mainly interested in group 13 and 14 metal alkoxides – catalysts for the ROP of cyclic esters leading to the formation of biodegradable polyesters, especially in the stereoselective catalysts for the ROP of lactide.  Notably, while our research has shown that gallium alkoxides with NHCs are highly active and stereoselective catalysts for the ROP of lactide, little is known about main group metal alkoxides or the aryloxides stabilized with N-heterocyclic carbenes. Thus, our current research work concerning group 13 and 14 metal alkoxides and aryloxides with NHCs focuses on the explanation of the role of NHC, as well as the character of the M–C(NHC) bond; on their structure and properties, including catalytic properties.

With regard to our studies on catalysts offering new possibilities of the synthesis of biodegradable polyesters, it should be noted that such polymers are of great interest due to their wide range of applications, including in medicine. In the course of our research, we develop synthetic methods and determine the structure of model metal alkoxides, as well as investigate the catalytic properties and application of selected catalysts in the synthesis of biodegradable polyesters. Determining the relationship between the structure of investigated complexes and their catalytic properties is a crucial part of our studies. We consider this approach especially important from the point of view of the synthesis of polyesters of desired structure and properties.

 

Paweł Horeglad, PhD, DSc
email: p.horeglad@cent.uw.edu.pl
phone: +48 22 55 43670
room: 02.172


Selected publications:


Probing the effect of six-membered N-heterocyclic carbene—6-Mes—on the synthesis, structure and reactivity of Me2MOR (NHC)(M= Ga, In) complexes
Cybularczyk-Cecotka, M., Dąbrowska, A. M., Guńka, P. A., & Horeglad, P. (2018).
Inorganics, 6(1), 28.
Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA-drug conjugates
Cybularczyk-Cecotka, M., Zaremba, R., Hurko, A., Plichta, A., Dranka, M., & Horeglad, P. (2017).
New Journal of Chemistry, 41(24), 14851-14854.
Towards NHC stabilized alkylgallium alkoxide/aryloxide cations – The advances, the limitations and the challenges
Dąbrowska, A. M., Hurko, A., Dranka, M., Varga, V., Urbańczyk, M., & Horeglad, P. (2017).
Journal of Organometallic Chemistry, 840, 63-69.
Controlling the stereoselectivity of rac-LA polymerization by chiral recognition induced formation of homochiral dimeric metal alkoxides
Horeglad, P., Cybularczyk, M., Litwińska, A., Dąbrowska, A. M., Dranka, M., Żukowska, G. Z., ... & Michalak, M. (2016)
Polymer Chemistry, 7(11), 2022-2036
Effect of In–CNHC Bonds on the Synthesis, Structure, and Reactivity of Dialkylindium Alkoxides: How Indium Compares to Gallium.
Cybularczyk, M., Dranka, M., Zachara, J., & Horeglad, P. (2016).
Organometallics, 35(19), 3311-3322.
Controlling the stereoselectivity of rac-LA polymerization by chiral recognition induced the formation of homochiral dimeric metal alkoxides.
Horeglad, P., Cybularczyk, M., Litwińska, A., Dąbrowska, A. M., Dranka, M., Żukowska, G. Z., M. Urbańczyk & Michalak, M. (2016)
Polymer Chemistry, 7(11), 2022-2036.
Effect of In-CNHC bonds on the synthesis, structure, and reactivity of dialkylindium alkoxides: How indium compares to gallium
Cybularczyk, M., Dranka, M., Zachara, J., & Horeglad, P. (2016)
Organometallics, 35(19), 3311-3322
Dialkylgallium alkoxides stabilized with N-heterocyclic carbenes: opportunities and limitations for the controlled and stereoselective polymerization of rac-lactide.
Horeglad, P., Cybularczyk, M., Trzaskowski, B., Żukowska, G. Z., Dranka, M., & Zachara, J. (2015).
Organometallics, 34(14), 3480-3496.
Polylactide conjugates of camptothecin with different drug release abilities.
Oledzka, E., Horeglad, P., Gruszczyńska, Z., Plichta, A., Nałęcz-Jawecki, G., & Sobczak, M. (2014).
Molecules, 19(12), 19460-19470.
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