Publication of Joanna Trylska in the Proceedings of the National Academy of Sciences

07 01 2025

Professor Joanna Trylska, head of the Laboratory of Biomolecular Machines at the University of Warsaw’s Centre of New Technologies, has published a paper entitled ‘Molecular dynamics in multidimensional space explains how mutations affect the association path of neomycin to a riboswitch’ in the prestigious Proceedings of the National Academy of Sciences. In this paper, in collaboration with scientists from the Japanese RIKEN Institute for Physical and Chemical Research, she elucidated the mechanism by which the well-known antibiotic neomycin binds to the riboswitch, an RNA molecule that functions to regulate gene expression.

Chyży P., Kulik M., Shinobu A., Re S., Sugita Y., Trylska J.
Molecular dynamics in multidimensional space explains how mutations affect the association pathway of neomycin to a riboswitch
(2024) Proceedings of the National Academy of Sciences of the United States of America, 121 (15), art. no. e2317197121
DOI: 10.1073/pnas.2317197121