New chemical modifications of mRNA – a publication in Advanced Science

08 01 2025

Researchers from the group of Jacek Jemielity, head of the Laboratory of Chemical Biology at the University of Warsaw’s Centre of New Technologies, have published a paper entitled “Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking” in the journal Advanced Science. In this work, they synthesized and characterized novel cap 5′ mRNA analogues for use in mRNA research. Informational RNA (mRNA) plays a central role in gene expression and is the target of many proteins that regulate protein biosynthesis. It has also emerged as a very attractive and flexible platform for new therapeutic strategies, including preventive vaccination (viral diseases), immunotherapy (cancer) or protein replacement therapies, which have already proven their efficacy during the COVID-19 pandemic.

Warminski M., Grab K., Szczepanski K., Spiewla T., Zuberek J., Kowalska J., Jemielity J.
Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking
(2024) Advanced Science, 11 (36), art. no. 2400994
DOI: 10.1002/advs.202400994