Laboratory of Stem Cells, Tissue Development and Regeneration
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ProfileProf. Krzysztof Kobielak Unveiling fundamental biological processes in adult stem cells regulation is important, since stem cells are not only required for physiological tissue or organ self-renewal but also play critical role during their regeneration after injury. Therefore understanding a precise regulation of adult stem cells homeostasis is very crucial since deregulation of stem cells self-renewal might result in organ failure or tumor formation. Thus, further discovery of the molecular factors tightly governing intrinsic balance of signaling pathways in stem cells is very important question in regenerative medicine and one of the goals of my laboratory. This knowledge might be very essential to understand a common mechanism of stem cells homeostasis and tissue regeneration and might be useful to adopt these basic discoveries to novel form of stem cell therapies in human. To address it, my laboratory will use independent skin stem cells from hair, sweat glands and nails as a model to decipher their molecular mechanism of regulation and their properties during skin, hair and limb/digit regeneration. Dissecting the underlying similarities and differences which occur during distinct skin appendages renewal may prove highly beneficial in unraveling the fundamental principles which govern tissue or organ regeneration in vivo. |
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LeaderMajor Areas of Research Interest Adult Stem Cells Education and scientific degrees 1999 – Ph.D. in medical sciences, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, 2019 – Habilitation degree in Biological Science (Faculty of Biology, University of Warsaw), 2020 – Associate Professor, University of Warsaw Professional background 2020 – currently Group Leader, Associate Professor, Laboratory of Stem Cells, Development and Tissue Regeneration, Centre of New Technologies (CeNT), The University of Warsaw (UW), Warsaw, Poland 2015 – 2020 Group Leader, Assistant Professor, Laboratory of Stem Cells, Development and Tissue Regeneration, Centre of New Technologies (CeNT), The University of Warsaw (UW), Warsaw, Poland 11/2015 currently Group Leader, Laboratory of Stem Cells, Development and Tissue Regeneration, Centre of New Technologies (CeNT), The University of Warsaw (UW), Warsaw, Poland 2007 – 2015 Assistant Professor, Head of the Laboratory in The Broad Center for Regenerative Medicine & Stem Cell Research, Department of Pathology, Keck School of Medicine, the University of Southern California (USC), Los Angeles, USA 2002 – 2007 Postdoctoral Associate, Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University (RU), New York, USA 2000 – 2002 Postdoctoral Associate, Howard Hughes Medical Institute, Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA 2000 – 2001 Adjunct, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, Poland 1997 – 2000 Assistant, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, Poland 1995-1997 Research Assistant, Graduate Student, Department of Biochemistry & Molecular Biology, University of Medical Sciences, Poznan, Poland Honors and Awards Opienska-Blauth First Prize, best paper presented by a student, 31st Meeting of the Polish Biochemical Society, Warsaw, Poland, 1995 Award from President of the Marcinkowski University for the best Ph.D. thesis, Poznan, Poland, 1999 FEBS Scholarship for Young Researcher, 26th Meeting of the Federation of European Biochemical Societies, Nice, France, 1999 Scholarship for Ph.D. Thesis founded by the State Committee for Scientific Research (KBM) (#4 P05B 063 13) for: Molecular analysis of DNA in Christ-Siemens-Touraine syndrome, 1999-2000 FEBS Scholarship for Young Researcher, 18th International Congress of Biochemistry and Molecular Biology, Birmingham, UK, 2000 Young Scholar Award, Foundation for Polish Science, Warsaw, Poland, 2000 Mozolowski First Prize, best paper presented by a doctoral student, 36th Meeting of the Polish Biochemical Society, Poznan, Poland, 2000 Project Leader (#4 P05 A 054 17) granted by the State Committee for Scientific Research (KBN) for: Anhydrotic ectodermal dysplasia as a model for differentiation of skin appendages, 2000-2001 Award from Polish Minister of Health for best paper published in 2003, 2004 Robert E and May R. Wright Foundation Award, 2009-2010 Donald E. and Delia B. Baxter Foundation Award, 2009-2010 Robert S. Cleland Excellence in Teaching Award (presented by USC graduate students), 2010-2011 |
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ContactProf. Krzysztof Kobielak |