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Profile
Prof. Marta Wiśniewska
e-mail: m.wisniewska@cent.uw.edu.pl
phone: +48 22 55 43690
room: 05.51
ORCID: 0000-0002-1593-0361
SCOPUS ID: 7003863560
Brain activity is based on propagation of electrical impulses along the axons of nerve cells and synaptic transmission. Neurons connect with one another to form electrical circuits, which are further grouped into systems that finally make a neural network. One of the systems is the thalamocortical complex – the center of perception and a regulator of the attention and awareness levels. Improper functioning of the thalamo-cortico-thalamic loop may result in some psychotic and affective disorders.
Laboratory of Molecular Neurobiology explores molecular mechanisms regulating thalamic identity and function. We are interested in transcriptional control over differentiation and maturation of thalamic neurons, and regulation of thalamic axon growth and guidance to the cerebral cortex. The effects of disturbed development and maintenance of thalamocortical circuits are also under our investigation. We work with primary neuronal cultures, organotypic cultures and in vivo models. We use a variety of molecular biology, biochemistry and cell biology techniques. Collaboration with bioinformations, electrophysiologists and behaviorists is always welcome.
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Selected publications
- Szewczyk L.M., Lipiec M.A., Liszewska E., Meyza K., Urban-Ciecko J., Kondrakiewicz L., Goncerzewicz A., Rafalko K., Krawczyk T.G., Bogaj K., Vainchtein I.D., Nakao-Inoue H., Puscian A., Knapska E., Sanders S.J., Jan Nowakowski T., Molofsky A.V., Wisniewska M.B.
Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior
(2024) Molecular Psychiatry, 29 (1), pp. 57 – 73
DOI: 10.1038/s41380-023-02281-y
- Brożko N., Baggio S., Lipiec M.A., Jankowska M., Szewczyk Ł.M., Gabriel M.O., Chakraborty C., Ferran J.L., Wiśniewska M.B.
Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish
(2022) Frontiers in Neuroanatomy, 16, art. no. 838567
DOI: 10.3389/fnana.2022.838567
- Balcerak A., Macech-Klicka E., Wakula M., Tomecki R., Goryca K., Rydzanicz M., Chmielarczyk M., Szostakowska-Rodzos M., Wisniewska M., Lyczek F., Helwak A., Tollervey D., Kudla G., Grzybowska E.A.
The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly
(2022) Cells, 11 (19), art. no. 2943DOI: 10.3390/cells11192943
DOI: 10.3390/cells11192943
- Płatek, R.; Rogujski, P.; Mazuryk, J.; Wiśniewska, M.B.; Kaczmarek, L.; Czupryn, A.
Impaired Generation of Transit-Amplifying Progenitors in the Adult Subventricular Zone of Cyclin D2 Knockout Mice
(2022) Cells 2022, 11, 135
DOI: 10.3390/cells11010135
- Brożko N, Baggio S, Lipiec MA, Jankowska M, Szewczyk ŁM, Gabriel MO, Chakraborty C, Ferran JL, Wiśniewska MB
Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish
(2022) Front Neuroanat. 2022 Mar 9;16:838567
DOI: 10.3389/fnana.2022.838567
- Sadowska M, Mehlhorn C, Średniawa W, Szewczyk ŁM, Szlachcic A, Urban P, Winiarski M, Jabłonka JA
Spreading Depressions and Periinfarct Spreading Depolarizations in the Context of Cortical Plasticity. Neuroscience
(2021) Neuroscience. 2021 Jan 15;453:81-101.
DOI: 10.1016/j.neuroscience.2020.10.032.
- Mazuryk, J.; Puchalska, I.; Koziński, K.; Ślusarz, M.J.; Ruczyński, J.; Rekowski, P.; Rogujski, P.; Płatek, R.; Wiśniewska, M.B.; Piotrowski, A.; et al.
PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
Int. J. Mol. Sci. 2021, 22, 6086
DOI: 10.3390/ijms22116086
- Lipiec M.A., Bem J., Kozinski K., Chakraborty C., Urban-Ciećko J., Zajkowski T., Dabrowski M., Szewczyk Ł.M., Toval A., Ferran J.L., Nagalski A., Wisniewska M.B.
TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus
(2020) Development (Cambridge), 147 (16), art. no. dev190181
DOI: 10.1242/dev.190181
- Setny P., Wisniewska M.D.
Water-mediated conformational preselection mechanism in substrate binding cooperativity to protein kinase A
(2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (15), pp. 3852 – 3857
DOI: 10.1073/pnas.1720024115
- Misztal K., Brozko N., Nagalski A., Szewczyk L.M., Krolak M., Brzozowska K., Kuznicki J., Wisniewska M.B.
TCF7L2 mediates the cellular and behavioral response to chronic lithium treatment in animal models
(2017) Neuropharmacology, 113, pp. 490 – 501
DOI: 10.1016/j.neuropharm.2016.10.027
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