Results of the competition:
The competition was not resolved.
Project title: Double-knotted proteins – limits of topological complexity of proteins,
OPUS 16 NCN
Project description: The goal of this project is to develop new methods to apply experimental data from NMR and single molecular manipulation to expand our knowledge of proteins with non-trivial topology. The aim is better understanding of the influence of non-trivial topology on fundamental biological mechanisms such as evolution, function and degradation. The project is interdisciplinary and involves aspects of mathematical knot theory, bioinformatics, computer simulations, biophysics, and both in vivo and in silico studies.
More information available at: https://konkursydlanauczycieli.uw.edu.pl/api/document/165/datafile/pdf
Tags: structural biology, enzymes, single force spectroscopy, protein degradation, molecular dynamics, co-evolution methods, statistical physics