Results of the competition:
As part of the conducted procedure, the Competition Committee recommended the candidacy of Adam Mamot, MSc and Mateusz Kozarski, MSc for the post of PhD student.
Position in the project: PhD
Scientific discipline: Organic chemistry, biochemistry, biophysics
Job type (employment contract/stipend): stipend
Number of job offers: 2
Remuneration/stipend amount/month): 4 000 PLN
Position starts on: 1st October 2018
Maximum period of contract/stipend agreement: 20 months
Institution: University of Warsaw, Centre of New Technologies
Project leader: Jacek Jemielity
Project title: New selective inhibitors of cap dependent proteins: synthesis, delivery and characterization
Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA cap analogs with potential medicinal applications. Laboratory of Bioorganic Chemistry is focused on the synthesis, properties and applications of modified nucleotides (including analogs of mRNA 5’ cap, nucleoside triphosphates, nucleotide sugars, nucleoside phosphosulfates and many others). The main goal of our research is to create tools useful for elucidating biological processes involving nucleotides and to find new potential nucleotide-derived therapeutics. To do so, we develop new synthetic methods for the chemical and enzymatic synthesis of nucleotides and their analogs. We are particularly interested in the synthesis and properties of nucleotides modified within the phosphate moieties. We design nucleotide analogs that increase cellular stability of mRNA and nucleotide-derived inhibitors of protein biosynthesis with increased stability under cellular conditions. We synthesize fluorescently labeled nucleotides, nucleotides with affinity tags as well as nucleotide-probes for NMR and EPR experiments. We also prepare and evaluate conjugates of nucleotides with nano(bio)materials. The selected doctoral candidates are expected to use cutting-edge bioorganic chemistry technologies within novel cap analogs synthesis of inhibitor conjugates. Studies will also focus on synthesis and preliminary characterization of fluorescently labelled molecular probes, developing and performing the screening studies, determination of IC 50 parameters and studies on inhibitor properties by orthogonal methods.
Key responsibilities include:
- PhD student 1: Bioorganic chemistry: new cap analogs synthesis, synthesis of cap-dependent protein inhibitors coniugates with agents promoting cell penetration, synthesis and initial characterization of fluorescently labeled molecular probes.
- PhD student 2: Biochemistry, biophysics: screening tests design and conduct, IC50 parameter determination, study of the properties of cap-dependent protein inhibitors by orthogonal methods
Profile of candidates/requirements:
- Master’s degree in Chemistry or another relevant field
- Great communication skills and a passion for life sciences
- Strong hands-on experience in organic chemistry techniques, with working knowledge of bioorganic compounds synthesis, purification and identification
- Practical experience with NMR, MS and HPLC support, NMR data analysis and graphic software is a big plus
- cover letter
- publications and conference presentations list
- reference contact list
- transcript of record from undergraduate studies
Please submit the following documents to: firstname.lastname@example.org
The best candidates will be invited to job interviews between July 16-27.
For more details about the position please visit: www.jemielitygroup.pl
Please include in your offer:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”