Brain activity is based on propagation of electrical impulses along the axons of nerve cells and synaptic transmission. Neurons connect with one another to form electrical circuits, which are further grouped into systems that finally make a neural network. One of the systems is the thalamocortical complex – the center of perception and a regulator of the attention and awareness levels. Improper functioning of the thalamo-cortico-thalamic loop may result in some psychotic and affective disorders.
Laboratory of Molecular Neurobiology explores molecular mechanisms regulating thalamic identity and function. We are interested in transcriptional control over differentiation and maturation of thalamic neurons, and regulation of thalamic axon growth and guidance to the cerebral cortex. The effects of disturbed development and maintenance of thalamocortical circuits are also under our investigation. We work with primary neuronal cultures, organotypic cultures and in vivo models. We use a variety of molecular biology, biochemistry and cell biology techniques. Collaboration with bioinformations, electrophysiologists and behaviorists is always welcome.
phone: +48 22 55 43690
room: 05.51
ACADEMIC DEGREES AND EDUCATION
27/09/2013 – Habilitation degree in Biological Science, Nencki Institute of Experimental Biology in Warsaw
6/10/2000 – PhD degree in Biological Science, Nencki Institute of Experimental Biology in Warsaw
29/07/1994 – Master thesis in Genetics, University of Warsaw
RESEARCH EXPERIENCE
2014 – present – Group Leader, Associate Professor (profesor UW), Centre of New Technologies, University of Warsaw
2013-2014 – Group Leader, Assistant Professor (adiunkt), Centre of New Technologies, University of Warsaw
2004-2013 – Senior Researcher, International Institute of Molecular and Cell Biology in Warsaw
2001-2004 – Postdoctoral Fellow, Pasteur Institute in Paris
1996 – Trainee, Pasteur Institute in Paris
1994-2000 – Research Assistant, Nencki Institute of Experimental Biology in Warsaw
MEMBERSHIPS AND AWARDS
2016 and 2020 – elected an extraordinary member of the Neurobiology Committee of the Polish Academy of Science
2019 – elected a member of the Polish Neuroscience Society Board
2015 – elected a member of the Warsaw Scientific Society
2013 – award of the Division of Biological Sciences, Polish Academy of Sciences, for a series of original research articles
2011 – Jerzy Konorski Prize for the best Polish publication in neurobiology in 2011, awarded by the Polish Neuroscience Society and Committee for Neurobiology of the Polish Academy of Sciences
OTHER PROFESSIONAL ACTIVITIES AND MEMBERSHIPS IN PROFESSIONAL BODIES
2021 – Scientific Committee member of the 15th International Congress of the Polish Neuroscience Society and Regional FENS Meeting
2020-2024 – scientific secretary in the presidium of the Neurobiology Committee of the Polish Academy of Science
2019-2021 – member of the executive committee of the Polish Neuroscience Society
2019 – present – Associate Editor at the Acta Neurobiologiae Experimentalis
2014 – Scientific Committee member of the 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics “BIO 2014”
2014 – Organising Committee member of the 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics “BIO 2014”
2014 – present – Scientific Council member of the Postgraduate School of Molecular Medicine (SMM)
ad hoc reviewer for Neuroscience, Acta Biochimica Polonica, Journal of Neurochemistry, International Journal of Biochemistry & Cell Biology, Scientific Reports, Translational Psychiatry, Current Drug Metabolism, Progress in Neurobiology, PLOS Biology, Molecular Neurobiology
SELECTED PUBLICATIONS
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Lipiec MA, Bem J, Koziński K, Chakraborty C, Urban-Ciećki J, Zajkowski T, Dąbrowski M, Szewczyk ŁM, Toval A, Ferran JL, Nagalski A, Wiśniewska MB; Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind; TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus. Development 08/2020; 147
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Bem J, Brozko N, Chakraborty C, Lipiec MA, Koziński K, Nagalski A, Szewczyk LM, Wisniewska MB; Wnt/β-catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind. FEBS Letters 07/2019; 593
- Misztal K, Brozko N, Nagalski A, Szewczyk LM, Krolak M, Brzozowska K, Kuznicki J, Wisniewska MB; TCF7L2 mediates the cellular and behavioral response to chronic lithium treatment in animal models. Neuropharmacology 10/2016; 113
- Nagalski A, Kozinski K, Wisniewska MB; Metabolic pathways in the periphery and brain: Contribution to mental disorders? Int J Cell Biol 2016; 80: 19-30
- Szewczyk LM, Brozko N, Nagalski A, Röckle I, Werneburg S, Hildebrandt H, Wisniewska MB, Kuznicki J; ST8SIA2 Promotes Oligodendrocyte Differentiation and the Integrity of myelin and axins. Glia 2016; 65: 34-49
- Nagalski A, Puelles L, Dabrowski M, Wegierski T, Kuznicki J, Wisniewska MB; Molecular anatomy of the thalamic complex and the underlying transcription factors. Brain Struct Funct 2016; 221: 2493-2510
- Mills F, Bartlett TE, Dissing-Olesen L, Wisniewska MB, Kuznicki J, Macvicar BA, Wang YT, Bamji SX; Cognitive flexibility and long-term depression (LTD) are impaired following -catenin stabilization in vivo. PNAS 2014; 111: 8631-8636
- Wisniewska MB; Physiological Role of β-catenin/TCF Signaling in Neurons of the Adult Brain. Neurochem Res 02/2013; 38: 1144-1155
- Wisniewska MB, Nagalski A, Dabrowski M, Misztal K, Kuznicki J; Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability. BMC Genomics 2012; 13; 635
- Nagalski A, Irimia M, Szewczyk L, Ferran JL, Misztal K, Kuznicki J, Wisniewska MB; Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain. Brain Struct Funct 2012; 218: 1531-1549
- Misztal K, Wisniewska MB, Ambrozkiewicz M, Nagalski A, Kuznicki J; WNT Protein-independent Constitutive Nuclear Localization of -Catenin Protein and Its Low Degradation Rate in Thalamic Neurons. J Biol Chem 2011; 286: 31781-31788
- Wisniewska MB, Misztal M, Michowski W, Szczot M, Purta E, Lesniak W, Klejman ME, Dabrowski M, Filipkowski RK, Nagalski A, Mozrzymas JW, Kuznicki J; LEF1/β -Catenin Complex Regulates Transcription of the Cav3.1 Calcium Channel Gene (Cacna1g) in Thalamic Neurons of the Adult Brain. J Neurosci 2010; 30: 4957-4969
Prof. Marta Barbara Wiśniewska
Postdoctoral Fellows:
Suelen Baggio, PhD
Łukasz Szewczyk, PhD
PhD students:
Michael Oluwatosin Gabriel, MSc
Katarzyna Hryniewiecka, MSc
Students:
Szymon Ławicki
Dorota Malicka
Alumni:
Chaitali Chakraborty, PhD
Tomasz Zajkowski, PhD
Andrzej Nagalaski, PhD
Kamil Koziński, PhD
Rafał Płatek, Piotr Rogujski, Jarosław Mazuryk, Marta B. Wiśniewska, Leszek Kaczmarek, Artur Czupryn
Cells 2022, 11(1),135
Nikola Brożko, Suelen Baggio, Marcin A. Lipiec, Marta Jankowska, Łukasz M. Szewczyk, Michael O. Gabriel, Chaitali Chakraborty, José L. Ferran, Marta B. Wiśniewska
Front. Neuroanat., 09 March 2022
Zajkowski T, Lee MD, Mondal SS, Carbajal A, Dec R, Brennock PD, Piast RW, Snyder JE, Bense NB, Dzwolak W, Jarosz DF, Rothschild LJ.
Mol Biol Evol. 2021
Sadowska, M., Mehlhorn, C., Średniawa, W., Szewczyk, Ł. M., Szlachcic, A., Urban, P., ... & Jabłonka, J. A
Neuroscience, 453, 81-101, 2021
Mazuryk J., Puchalska I., Koziński K., Ślusarz M.J., Ruczyński J., Rekowski P., Rogujski P., Płatek R., Wiśniewska M.B., Piotrowski A., Janus Ł, Skowron P.M., Pikuła M., Sachadyn P., Rodziewicz-Motowidło S., Czupryn A., Mucha P.
International Journal of Molecular Sciences 22(11), 6086
Wakana Sato, Tomasz Zajkowski, Felix Moser, Katarzyna P. Adamala
Wiley Interdiscip Rev Nanomed Nanobiotechnol, e1761
Dawid Mehlich, Michał Łomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Łukasz M Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K Prełowska, Adam Gorczyński, Paweł Jabłoński, Ewa Iżycka-Świeszewska, Dominika Nowis, Anna A Marusiak
Cell Death & Disease, Vol. 12, Art. No. 1111 No. 1111
Ewa K. Nawrocka, Mateusz Urbańczyk, Kamil Kozińskia , Krzysztof Kazimierczuk
RSC Advances, 2021,11, 35321-35325
Lipiec M.A., Bem J., Koziński K., Chakraborty C., Urban-Ciećko J., Zajkowski T., Dąbrowski M., Szewczyk Ł.M., Angel Toval A., Ferran J.L., Nagalski A., Wiśniewska M.B.
Development (2020)
Sardar D., Cheng Y-T., Szewczyk L.M., Deneen B., Molofsky A.V.
Patterning and Cell Type Specification in the Developing CNS and PNS- Second Edition, 2020
Bem, J., Brożko, N., Chakraborty, C., Lipiec, M. A., Koziński, K., Nagalski, A., ... & Wiśniewska, M. B.
FEBS letters, 593 (13), 1654-1674
Lipiec, M. A., & Wiśniewska, M. B.
Postępy Biochemii, 65(2), 135-142
Nieznanska, H., Bandyszewska, M., Surewicz, K., Zajkowski, T., Surewicz, W. K., & Nieznanski, K. (2018).
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(6), 2143-2153
Misztal, K., Brozko, N., Nagalski, A., Szewczyk, L. M., Krolak, M., Brzozowska, K., ... & Wisniewska, M. B. (2017).
Neuropharmacology, 113, 490-501.
Szewczyk, L. M., Brozko, N., Nagalski, A., Röckle, I., Werneburg, S., Hildebrandt, H., ... & Kuznicki, J. (2017).
Glia, 65(1), 34-49.
Nagalski, A., Kozinski, K., & Wisniewska, M. B. (2016).
The international journal of biochemistry & cell biology, 80, 19-30.
Nagalski, A., Puelles, L., Dabrowski, M., Wegierski, T., Kuznicki, J., & Wisniewska, M. B. (2016).
Brain Structure and Function, 221(5), 2493-2510.
| Title | Deadline for applications |
|---|---|
| PhD Student (CeNT-54-2021) | 10/01/2022 |
| Postdoc (Adjunct) in the group of researchers in the Laboratory of Molecular Neurobiology | 22/07/2021 |
| PhD Student in the Laboratory of Molecular Neurobiology | 25/06/2021 |
| Postdoc (Adjunct) in the Laboratory of Molecular Neurobiology | 16/05/2021 |
| Postdoc (Adjunct) in the Laboratory of Molecular Neurobiology | 16/05/2021 |
| PhD student in Laboratory of Molecular Neurobiology | 07/12/2019 |
