Groundbreaking work on enhancing mRNA vaccine efficacy published in Nature
17 04 2025
Category: CeNT news, Main page, Research highlights
A groundbreaking study by Polish scientists, published in the journal Nature, clarifies the mechanism of mRNA drug efficacy and opens the way to new therapies. The team of authors of this publication included more than twenty authors, including scientists from Jacek Jemielity Laboratory of Chemical Biology at the University of Warsaw’s Centre for New Technologies.
The research results have also inspired the creation of an innovative educational program. A new master’s degree course in Biological Therapeutics will be launched at the Faculty of Medicine of the University of Warsaw in October and is co-developed by the International Institute of Molecular and Cell Biology. The course will train future specialists in biotechnology, biological drugs and mRNA-based therapies.
Paweł S. Krawczyk, Michał Mazur, Wiktoria Orzeł, Olga Gewartowska, Sebastian Jeleń, Wiktor Antczak, Karolina Kasztelan, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Natalia Gumińska, Bartosz Tarkowski, Ewelina P. Owczarek, Kamila Affek, Paweł Turowski, Agnieszka Tudek, Małgorzata Sroka, Tomasz Śpiewla, Monika Kusio-Kobiałka, Aleksandra Wesołowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek, “Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines”, Nature. https://doi.org/10.1038/s41586-025-08842-1