CeNT
herb

Laboratorium Bioinformatyki i Biologii Systemów

Badania prowadzone w Laboratorium Bioinformatyki i Biologii Systemów mają charakter interdyscyplinarny z pogranicza biologii, chemii, fizyki oraz matematyki. Badania te mają na celu zarówno rozwijanie nowych narzędzi bioinformatycznych, jak i ich zastosowanie w połączeniu z metodami współczesnej biologii molekularnej do badania struktury, funkcji i ewolucji białek oraz ich oddziaływań z ligandami, ze szczególnym uwzględnieniem istotnych procesów biologicznych takich jak metylacja i metabolizm kwasów nukleinowych.

Obszarem zainteresowań zespołu LBBS są również badania genomów, transkryptomów i metagenomów prowadzone z wykorzystaniem sekwencjonowania nowej generacji w oparciu o system Illumina.

Krzysztof Ginalski, prof.
email: k.ginalski@cent.uw.edu.pl
phone: 40833
room: 2151 (II siedziba)


“Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.”
Aymard, François, Marion Aguirrebengoa, Emmanuelle Guillou, Biola M. Javierre, Beatrix Bugler, Coline Arnould, Vincent Rocher et al.
Nature Structural & Molecular Biology (2017)
“Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.”
Shi, Wei, Therese Vu, Didier Boucher, Anna Biernacka, Jules Nde, Raj K. Pandita, Jasmin Straube et al.
Blood 129, no. 18 (2017): 2479-2492.
“Phylogeny-based systematization of Arabidopsis proteins with histone H1 globular domain.”
Kotliński, Maciej, Lukasz Knizewski, Anna Muszewska, Kinga Rutowicz, Maciej Lirski, Anja Schmidt, Célia Baroux, Krzysztof Ginalski, and Andrzej Jerzmanowski.
Plant physiology 174, no. 1 (2017): 27-34.
“Comprehensive classification of the PIN domain-like superfamily.”
Matelska Dorota, Kamil Steczkiewicz, and Krzysztof Ginalski
Nucleic Acids Research (2017)
“A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase.”
Kulecka, Maria, Aldona Wierzbicka, Agnieszka Paziewska, Michal Mikula, Andrzej Habior, Wojciech Janczyk, Michalina Dabrowska et al
Journal of Hepatology 67, no. 5 (2017): 1026-1030
“Fungal lifestyle reflected in serine protease repertoire.”
Muszewska, Anna, Marta M. Stepniewska-Dziubinska, Kamil Steczkiewicz, Julia Pawlowska, Agata Dziedzic, and Krzysztof Ginalski.
Scientific Reports 7, no. 1 (2017): 9147
“Diverse cap-binding properties of Drosophila eIF4E isoforms.”
Zuberek, Joanna, Krzysztof Kuchta, Greco Hernández, Nahum Sonenberg, and Krzysztof Ginalski.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864, no. 10 (2016): 1292-1303.
Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using Illumina platform
Mitra, A., Skrzypczak, M., Ginalski, K., & Rowicka, M.
PloS one, 10(4), e0120520
“Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding.”
Kropiwnicka, Anna, Krzysztof Kuchta, Maciej Lukaszewicz, Joanna Kowalska, Jacek Jemielity, Krzysztof Ginalski, Edward Darzynkiewicz, and Joanna Zuberek
Biochemical and biophysical research communications 456, no. 1 (2015): 47-52
Phylogenetic analysis (including use of related software) especially in relation to fungi
Muszewska, A., Ginalski, K.
Molecular Biology of Food and Water Borne Mycotoxigenic and Mycotic Fungi, Russell R., Paterson M., CRC Press 2015
“Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding.”
Kropiwnicka, Anna, Krzysztof Kuchta, Maciej Lukaszewicz, Joanna Kowalska, Jacek Jemielity, Krzysztof Ginalski, Edward Darzynkiewicz, and Joanna Zuberek
Biochemical and biophysical research communications 456, no. 1 (2015): 47-52
“The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.”
Yoshida, Kazumasa, Julien Bacal, Damien Desmarais, Ismaël Padioleau, Olga Tsaponina, Andrei Chabes, Véronique Pantesco et al
Molecular cell 54, no. 4 (2014): 691-697
“HarmonyDOCK: the structural analysis of poses in protein-ligand docking.”
Plewczynski, Dariusz, Anna Philips, Marcin Von Grotthuss, Leszek Rychlewski, and Krzysztof Ginalski
Journal of Computational Biology 21, no. 3 (2014): 247-256
“DIRS and Ngaro retrotransposons in fungi.”
Muszewska, Anna, Kamil Steczkiewicz, and Krzysztof Ginalski
PLoS one 8, no. 9 (2013): e76319
“Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels.”
Szczesny, Roman J., Monika S. Hejnowicz, Kamil Steczkiewicz, Anna Muszewska, Lukasz S. Borowski, Krzysztof Ginalski, and Andrzej Dziembowski
Nucleic acids research 41, no. 5 (2013): 3144-3161
“Sequence, structure and functional diversity of PD-(D/E) XK phosphodiesterase superfamily.”
Steczkiewicz, Kamil, Anna Muszewska, Lukasz Knizewski, Leszek Rychlewski, and Krzysztof Ginalski
Nucleic acids research 40, no. 15 (2012): 7016-7045
“C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3′ end modification.”
Mroczek, Seweryn, Joanna Krwawicz, Jan Kutner, Michal Lazniewski, Iwo Kuciński, Krzysztof Ginalski, and Andrzej Dziembowski
Genes & development 26, no. 17 (2012): 1911-1925
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