iCell: information processing in living organisms. The role of three-dimensional structure and multi-scale properties in controlling the biological processes in a cell.

Project Leader: Prof. Dariusz Plewczyński Project period: 2015 - 2019
Project funding: OPUS, NCN
Project description:

iCell project proposes the development of a novel theoretical framework for multiscale modelling of living organisms in the context of information processing. The basic biological information is stored in digital form in the DNA (or RNA in certain organisms). This information determines the activity of intracellular signalling pathways defining the analogue cell function, followed by tissue, organ, and finally the whole body organization of a system. The aim of the project is to provide research instruments to study multiscale processes in living organisms, which are related to the processing of information. Our proposed research is related to the modelling of transitions between different scales, in particular how the information at the micro level determines the phenotype at the macro level, but also as behavioral factors related to communication between individuals of the same species or others are substancing at the genetic level. We plan to build a network model of the cell represents the known interactions tween biomolecules for specific prokaryotic and eukaryotic cells, with spatial information about their location. Then, using the network model we analyze observed in the cells of multi-scale biophysical phenomena that are associated with information processing and communication, and population-environment. A new model of the cell you put in a broader context, highlighting the level of tissues and organs, with particular emphasis on neural systems, and neoplastic lesions.

Laboratory of Functional and Structural Genomics