Results of the competition:
As a result of the conducted competition, the competition committee has recommended Kamil Ziemkiewicz for the position.
Project title: mRNA 5′ end methylation status: towards deeper understanding of biological role and identification of synthetic mimics, OPUS 17, NCN.
Project description: The aim of the project is to understand how the methylation status at the 5’ end of mRNA cap structure and the few neighboring nucleotides influences biochemical properties of mRNA such as translation, turnover, and immunogenicity. These properties are of crucial importance for applicability of mRNA in gene therapies, therefore this knowledge can be used for tailoring structure of mRNA 5’ end to various therapeutic applications. The studies will cover the modifications within ribose of the first (cap 1) and the second transcribed nucleotide (cap 2) as well as methylation of the bases including 6-methyl adenosine (m6A) and 5-methylcytosine.
For more information about the position, please visit: https://www.uw.edu.pl/wp-content/uploads/2020/02/job-offer_phd-student_cent_until-05-may.pdf
Tags: nucleotide synthesis, mRNA 5' cap, therapeutic mRNA