Results of the competition:
By means of the conducted competition, the competition committee has recommended Iwona Lewandowska for the position of PhD Student in the project.
Description:
Director of Centre of New Technologies of the University of Warsaw, with the Project Leader, announce opening of the competition for the position of PhD Student in the Interdisciplinary Laboratory of Biological Systems Modelling – Centre of New Technologies of the University of Warsaw.
Position in the project: PhD Student
Laboratory: Interdisciplinary Laboratory of Biological Systems Modelling
Scientific discipline: Chemical Sciences, Physical Sciences, Pharmaceutical Sciences
Keywords: structural biology, enzymes, single force spectroscopy, protein degradation, NMR , X-rey advance numerical simulations, structure prediction, transition state,
equilibrium thermodynamics concepts, pylemres, topology
Job type (employment contract/stipend): stipend, part-time or full time
Number of job offers: 1
Stipend amount/month: 2000-4000 PLN gross gross
Position starts on: 1.10.2020
Maximum period of contract/stipend agreement: 24 months, with the possibility of extension up to 36 months
Institution: Centre of New Technologies, University of Warsaw
Project leader: Professor Joanna Sułkowska
Project title: Double-knotted proteins – limits of topological complexity of proteins
Competition type: OPUS 16
Financing institution: NCN
Project description:
The aim is better understanding of the influence of non-trivial topology on fundamental biological mechanisms such as evolution, function and degradation. The project is interdisciplinary and involves aspects of mathematical knot theory, bioinformatics, computer simulations, physics (exploring fundamental characteristics of the response, such as average transition stress and hysteresis, application of computer simulations including conventional techniques and machine learning. Formulation of a set of equations for the evolution of the probability density of meta-stable configurations for polymers with non-trivial topology. ), biology and both in vivo and in silico studies.
Key responsibilities include:
The role of applicant will be either to conduct experimental investigation of knotted proteins based on structural biology study, NMR or on the single molecule approach or include experimental data into computational study as well as develop new methods to understand fundamental features of transition states, reversibility, equilibrium thermodynamics concepts, pattern formation processes and the underlying physical mechanisms which determine free energy landscape of proteins with non-trivial topology. Addressing
questions such as conversion problem, a choice of reaction coordinates, etc.
Profile of candidates/requirements:
The competition is open for persons who meet the conditions specified in the regulations on the allocation of resources for the implementation of tasks financed by the National Science Centre for OPUS 16 grant.
The successful PhD candidate will have a MSc degree or equivalent in chemistry/biology/pharmacy or physics.
The MSc degree or equivalent should be obtained before the date of employment in the project – by 30.09.2020 at the latest;
– Confirmed status of a PhD student on the day of starting the work in the project (01.10.2020).
To receive the stipend, the successful candidate needs to have a PhD student status at a Polish university either in a PhD programme or in a
Doctoral School of Exact and Natural Sciences (e.g., at University of Warsaw registration deadline is 28.06.2020, https://szkolydoktorskie.uw.edu.pl/en/), according to standing
procedures.
Good experience either in structural biology, purification of proteins, NMR techniques, or in conducting molecular modeling simulations, multiscaling modeling, programs such as Modeller, Rosetta. Experience with highperformance computing, knowledge of c++ or Python and scientific computing libraries and Linux environment is necessary. Very good understanding of soft condenst matter physics, statistical physics would be welcome.
Required documents:
1. Cover letter;
2. Current curriculum vitae;
3. Copy of MSc certificate (or, if the MSc certificate has not been obtained yet, a certificate/document about the date of MSc defense);
4. Two letters of recommendation
We offer:
An opportunity to participate in a multidisciplinary project in one of the best scientific institutions in Poland. Stimulating, young and friendly work environment. Access to high quality structural biology laboratory, as well as, high-end computing equipment (CPU clusters).
Opportunity to participate in EUTOPIA COST network and various practical EMBO workshops.
Please submit the application documents to: j.sulkowska@cent.uw.edu.pl
Application deadline: 31.07.2020
Date of announcing the results: 18.08.2020
Method of notification about the results: e-mail
To allow us to process your data, please include in your application the signed information on the personal data processing, available at: http://bsp.adm.uw.edu.pl/bsp/druki-i-formularze/
Information about the competition is also available on the website of the University of Warsaw.
Deadline: 31/07/2020
Tags: structural biology, enzymes, single force spectroscopy, protein degradation, NMR , X-rey advance numerical simulations, structure prediction, transition state, equilibrium thermodynamics concepts, pylemres, topology
