Description:
Title of the position: PhD student in Laboratory of Structural Bioinformatics
Scientific discipline: Bioinformatics
Job type: Scholarship
Number of job offers: 1
Remuneration/Stipend amount/month: 4500
Position starts on: 01.10.2019
Maximum period of contract/stipend agreement: 28 months
Institution: Laboratory of Structural Bioinformatics
Project leader: Stanisław Dunin-Horkawicz
Project title: An evolutionary-based approach to design the substrate specificity of the Rossmann fold enzymes
Project Description: The goal of the project is to understand the evolution of the Rossmann fold, one of the most prominent protein folds encompassing enzymes with >300 different functions. With the aid of bioinformatics methods, including machine learning and molecular simulations, we will reveal the principles that define the cofactor specificity in Rossmann enzymes. These principles will be used to build a “toolkit” for rational re-engineering of cofactor specificity. The proposed project involves collaboration with two partners: (i) Core Facility for Crystallography and Biophysics, University of Warsaw (Poland) and (ii) Department of Biomolecular Sciences, Weizmann Institute of Science (Israel). Project is carried out within the FIRST TEAM programme of the Foundation for Polish Science
Key responsibilities include:
Design and implementation of machine learning tools for protein sequence and structure analysis
Profile of candidates/requirements:
1. Good knowledge of Python and scientific computing libraries (sci-kit, numpy, pandas, biopython). Experience with high-performance computing and Linux environment
2. Previous experience in machine learning and bioinformatics tools (some of the following: protein sequence/structure analysis, protein design, molecular dynamics, phylogenetic analysis)
3. Good writing and oral communication skills in English
Required documents:
1. A copy of a MSc certificate
2. A short CV
3. A short cover letter
4. Contact details of one academic researcher willing to provide a recommendation letter for the Candidate
We offer:
1. An opportunity to participate in a multidisciplinary project conducted in a collaboration with scientists from Poland (University of Warsaw) and Israel (Weizmann Institute of Science)
2. The stimulating and very friendly work environment
3. Access to the high-end computing equipment (CPU and GPU clusters)
Please submit the following documents to: s.dunin-horkawicz@cent.uw.edu.pl
- RODO
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Deadline: 15/07/2019
Attachment: download
Tags: Bioinformatics, protein evolution, machine learning
