Description:
Title of the position: PhD student in Laboratory of Experimental Medicine
Scientific discipline: immunology and immunotherapy of cancer
Job type: Scholarship
Number of job offers: 2
Remuneration/Stipend amount/month: 3000
Position starts on: 02.09.2019
Maximum period of contract/stipend agreement: until 2020-06-30 (10 months)
Institution: Laboratory of Experimental Medicine
Project leader: prof. Dominika Nowis
Project title: The role of arginase-1 in antitumor efficacy of cancer immunotherapy using checkpoint inhibitors
Project Description: Previous studies and our preliminary findings reveal that one potential mechanism involved in the interference with anti-tumor immune effector mechanism might involve the activity of arginase-1, an enzyme that degrades L-arginine in the tumor microenvironment. In the absence of L-arginine T lymphocytes cannot be activated due to decreased levels of components of the antigen recognition system. Therefore, using both genetically engineered tumor models as well as antibodies against check-point molecules we plan to determine whether arginase-1 is a potentially druggable target for the combination immunotherapy. This knowledge is necessary to better understand molecular mechanisms involved in the development of tumor-associated immune response. The results of this project might also be helpful in identifying novel targets for cancer treatment, better understanding of the shortcomings and adverse effects observed in cancer patients undergoing cancer immunotherapies and in finding novel areas to be exploited in the fields of immunology and experimental oncology. Even if the role of arginase-1 would turn out to be important only in a subgroup of patients, the results of this project might be of great clinical importance.
Key responsibilities include:
Planning and execution of experiments in the animal models of cancer, data analysis, preparation of presentations, scientific posters and research publications.
Profile of candidates/requirements:
– M.Sc. degree (or equivalent) in biology or medical sciences
– at least 1 outstanding scientific publication in a peer-reviewed international journal
– experience in basic laboratory techniques (e.g. Western blotting, PCR, molecular cloning, cell culture)
– experience in animal work (at least 12 months)
– experience in multicolor flow cytometry
– good communication skills in written and oral English
– ability to work efficiently within a team
– involvement in PhD studies
Required documents:
• Letter of intent
• CV
• One letter of reference
• copy of M.Sc. diploma
We offer:
• employment in a rapidly developing University of Warsaw institute
• lab and office space
• basic equipment and core facilities
• substantive and organizational support
• friendly, inspiring, interdisciplinary environment
Please submit the following documents to: d.nowis@cent.uw.edu.pl
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- The Controller of your personal data is the University of Warsaw with its registered office at KrakowskiePrzedmieście 26/28, 00-927 Warszawa;
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Deadline: 30/06/2019
Tags: tumor, immune response, immunotherapy, arginase, checkpoint inhibitors, cell culture, in vivo mouse tumor models, molecular biology
