Title: Synthetic and mechanistic studies on reactions involving hypervalent iodine compounds

Date: 12th March 2021 (Friday)

Time: 12:00 pm (Central European Time)

Host: prof. Joanna Trylska

Virtual seminar:https://us02web.zoom.us/j/89991524964

Meeting ID: 899 9152 4964

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Abstract:

Over the recent years, the application of hypervalent iodine compounds in organic synthesis has been the subject of intensive research, and nowadays, hypervalent iodine reagents and catalysts occupy a well-established place in the organic chemist toolbox. In particular, they allow for performing advanced oxidation reactions, which involve the formation of new chemical bonds and lead to a large increase in the molecular complexity. The strong motivation for the development of new hypervalent iodine species and novel synthetic methods employing them stems also from the low toxicity and cost of iodine and its compounds, fitting perfectly into the philosophy of green and sustainable chemical synthesis.

Since its establishment in 2016, our laboratory at CeNT UW has been active in the research on the chemistry of hypervalent iodine in the context of organic synthesis and has made some important contributions in this area. During the seminar, the development of new synthetic methods employing hypervalent iodine reagents will be presented. These include a number of metal-free C–H functionalizations with iodonium salts as group transfer reagents, as well as transformations, wherein hypervalent iodine species are used as oxidants. The results of our experimental and computational investigations on the mechanisms of selected synthetically useful processes involving hypervalent iodine will also be discussed.