A team of scientists from the Faculty of Physics of the University of Warsaw and the Centre of New Technologies of the University of Warsaw, promoters: dr hab. Joanna Kowalska, dr Marcin Warmiński, prof. Jacek Jemielity and Marek Baranowski, published in the prestigious scientific journal Nucleic Acids Research (NAR) the results of experiments on the synthesis and characterization of fluorine-labeled oligonucleotides at one end of a nucleic acid (DNA) strand and their applications in fluorine nuclear magnetic resonance (19F NMR).
This publication was recognized by reviewers as “Breakthrough Paper” – a groundbreaking article for the development of science.
The described compounds are a new type of molecular probe for the simple detection of various spatial DNA variants (so-called secondary structures), such as double-stranded fragments (duplexes), as well as more unusual structures – the so-called non-canonical structures (G-quadruplexes and i-motifs). Fluorine-labeled DNA fragments allow the study of these structures using a structural-sensitive method, 19F NMR spectroscopy.
The text of University of Warsaw publications is available on the Nucleic Acids Research website at: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa470/5854145
