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A new method for the chemical production of circular mRNAs

Category: Main page, Research highlights, Science news

A research team led by Professor Jacek Jemielity, head of the  Laboratory of Chemical Biology at the Centre of New Technologies, University of Warsaw, and Joanna Kowalska, has developed a novel chemical method for obtaining circular mRNA molecules. This opens up new possibilities in the design of stable and effective RNA-based drugs. The results of the research have been published in the journal Nature Communications.

The new technique, called chem-circRNA, allows the efficient circularisation of RNA molecules produced by in vitro transcription, with lengths ranging from 35 to as much as 4,000 nucleotides, with efficiencies of more than 60%. It uses a reducing amination reaction between the modified 5′ end and the oxidised 3′ end of the RNA, eliminating limitations typical of enzymatic or autocatalytic methods, such as sequence dependence or low efficiency.

More information:

https://serwisnaukowy.uw.edu.pl/mrna-zamkniete-w-kolko-polscy-naukowcy-zrobili-to-pierwsi-na-swiecie/

Nowa metoda chemicznego wytwarzania kolistych mRNA

Wasinska‑Kalwa M., Mamot A., Czubak K., … Kowalska J., Jemielity J. , Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design, „Nature Communications” 16, 6455 (2025). DOI: 10.1038/s41467-025-61775-1