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Breakthough in Biology: Polish Scientists Discover Previously Unknown Protein Structures

Category: Main page, Research highlights, Science news

An international research team led by Dr. Joanna Sułkowska (CeNT, University of Warsaw) has published the results of a study in the prestigious journal *Proceedings of the National Academy of Sciences* (PNAS) that is changing our understanding of the architecture of life. The researchers described the first crystal structures of proteins with a previously unknown motif among solenoid-type proteins—so-called Knotted Solenoids. Crucially, the existence of this unique form had previously been suggested by artificial intelligence (AlphaFold)—though it seemed unlikely. Nevertheless, the Polish research provided definitive, experimental proof that AI algorithms can accurately design even the most topologically complex secrets of nature.

Maciej Sikora, Mariusz Mozajew, Julia A. Sikorska, Fernando Bruno da Silva, Agata P. Perlinska, Anna Kluza, Szymon Niewieczerzal, Maciej Lukaszewicz, Beata Wielgus-Kutrowska, Karolina Stachurska-Korzeniowska, Sophie E. Jackson, Joanna I. Sulkowska, Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 31 topology, Proceedings of the National Academy of Sciences, 123 (17) e2525920123.