Most read publication in Protein Science by authors from the Centre of New Technologies
17 04 2025
Category: CeNT news, Main page, Science news
The publication “AlphaFold predicts novel human proteins with knots” by Agata P. Perlinska, Wanda H. Niemyska, Bartosz A. Gren, Marek Bukowicki, Szymon Nowakowski, Pawel Rubach and Joanna I. Sulkowska from the Interdisciplinary Laboratory of Biological Systems Modelling, Centre of New Technologies, University of Warsaw is one of the most read publications of Protein Science journal within the last two years. Authors analyzed all proteins from the human proteome (over 20,000) determined with AlphaFold in search for knots and found them in less than 2% of the structures. Using a variety of methods, including homolog search, clustering, quality assessment, and visual inspection, they determined the nature of each of the knotted structures and classified it as either knotted, potentially knotted, or an artifact, and deposited all of them in a database available at: https://knotprot.cent.uw.edu.pl/alphafold. Overall, they found 51 credible knotted proteins (0.2% of human proteome).