Profile
Leader
Team
Projects
Publications
Contact
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Profile
Prof. Marcin Kałek
e-mail: m.kalek@cent.uw.edu.pl
phone: +48 22 55 43730
room: 03.45
ORCID: 0000-0002-1595-9818
SCOPUS ID: 23027533100
The research in our laboratory is aimed at the development of new, efficient methodologies for synthetic organic chemistry.
Currently, our research interests concentrate on the use of hypervalent iodine, whose unique properties allow for performing advanced oxidation reactions, which involve the formation of new chemical bonds and lead to a large increase in the molecular complexity. These include group-transfer processes, wherein a substituent is transferred from a stoichiometric hypervalent iodine reagent onto an organic acceptor, as well as hypervalent iodine-promoted oxidations that may be carried out using a catalytic amount of the iodine-containing compound. Recently, we have also initiated research into the application of electric energy for driving the oxidation of organic substrates, using iodoarenes as electrocatalysts.
A key element of our work are also investigations of chemical reaction mechanisms, which are conducted both using experimental and computational approaches.
Please visit our Group Website for more details. |
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Selected publications
- Tomczyk I., Kalek M.
Electrochemical Dearomatizing Methoxylation of Phenols and Naphthols: Synthetic and Computational Studies
(2024) Chemistry – A European Journal, 30 (20), art. no. e202303916
DOI: 10.1002/chem.202303916
- Bernard R.S., Jha A.K., Kalek M.
Electrochemical oxidations through hypervalent iodine redox catalysis
(2024) Tetrahedron Chem, 11, art. no. 100081
DOI: 10.1016/j.tchem.2024.100081
- Sarkar S., Kalek M.
Metal-Free S-Arylation of Phosphorothioate Diesters and Related Compounds with Diaryliodonium Salts
(2023) Organic Letters, 25 (4), pp. 671 – 675
DOI: 10.1021/acs.orglett.2c04310
- Wojciechowska, N., Bienkowski, K., Solarska, R., Kalek, M.
Electrochemical Asymmetric Diacetoxylation of Styrenes Mediated by Chiral Iodoarene Catalyst
(2023) European Journal of Organic Chemistry 26(32), e202300477
DOI: 10.1002/ejoc.202300477
- Sarvi Beigbaghlou, S., Yafele, R. S., Kalek, M.
Electrochemical Dearomatizing Spirolactonization and Spiroetherification of Naphthols and Phenols
(2023) Synthesis 55(24), 4173-4180
DOI: 10.1055/a-2128-5408
- Jedrzejewski, M., Belza, B., Lewandowska, I., Sadlej, M., Perlinska, A. P., Augustyniak, R., Christian, T., Hou, Y.-M., Kalek, M., Sulkowska, J. I.
Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study
(2023) Computational and Structural Biotechnology Journal 21, 3999-4008
DOI: 10.1016/j.csbj.2023.08.001
- Jacquet M., Osella S., Harputlu E., Pałys B., Kaczmarek M., Nawrocka E.K., Rajkiewicz A.A., Kalek M., Michałowski P.P., Trzaskowski B., Unlu C.G., Lisowski W., Pisarek M., Kazimierczuk https://dx.doi.org/10.1055/a-2128-5408K., Ocakoglu K., Wiȩckowska A., Kargul J.
Diazonium-Based Covalent Molecular Wiring of Single-Layer Graphene Leads to Enhanced Unidirectional Photocurrent Generation through the p-doping Effect
(2022) Chemistry of Materials, 34 (8), pp. 3744 – 3758
DOI: 10.1021/acs.chemmater.2c00088
- Pareek A., Kalek M.
Regioselective Dearomatization of N-Alkylquinolinium and Pyridinium Salts under Morita-Baylis-Hillman Conditions
(2022) Advanced Synthesis and Catalysis, 364 (16), pp. 2846 – 2851
DOI: 10.1002/adsc.202200429
- Sarkar S., Wojciechowska N., Rajkiewicz A.A., Kalek M.
Synthesis of Aryl Sulfides by Metal-Free Arylation of Thiols with Diaryliodonium Salts under Basic Conditions**
(2022) European Journal of Organic Chemistry, 2022 (2), art. no. e202101408
DOI: 10.1002/ejoc.202101408
- Kraszewski K., Tomczyk I., Kalek M.
Intermolecular enantioselective dearomatizing para-methoxylation of phenols using 2-iodoresorcinol/lactamide catalysts
(2022) Tetrahedron Letters, 108, art. no. 154127
DOI: 10.1016/j.tetlet.2022.154127
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