Title of the position: MSc student in Laboratory of Functional and Structural Genomics
Scientific discipline: molecular biology, biotechnology, next generation sequencing, the role of 3D chromatin structure in storing, processing and evolving biological information; Spatiotemporal 4D genome organization and transcription regulation in human population, bioimaging, chromosome painting.
Job type: Scholarship
Number of job offers: 1
Remuneration/Stipend amount/month: 2500
Position starts on: 2019-05-01
Maximum period of contract/stipend agreement: 5 with the option for extension up to 17 months
Institution: Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw
Project leader: Dariusz Plewczynski
Project title: Three-dimensional Human Genome structure at the population scale: computational algorithm and experimental validation for lymphoblastoid cell lines of selected families from 1000 Genomes Project
Project Description: The aim of the research project is to explore at the population scale the relation between the three-dimensional structure variability of Human cell nucleus, and the emergence and the nature of the genomic sequence alterations. The research team will use public and proprietary experimental results of large-scale next-generation sequencing studies, and recently developed theoretical algorithms. The project will establish novel multi-scale computer method that is able to predict the 3D structure of genome for an individual using only its 1D genomic sequence (the list of structural variants SVs) by applying biopolymer theory, statistical learning and the biophysical properties of chromatin. The results will be validated by chromatin conformation capture experiments for selected families from 1000 Genomes Project, with the additional aim to better understand both normal and pathological structural changes occurring during evolution of Human genome.
Key responsibilities include:
The immortalization of patient-derived cells. The extensive work within 3D genomics field including NGS-based approaches like Hi-C, Hi-ChIP, ChIA-PET. Experimental data analysis.
Profile of candidates/requirements:
1. Bachelor degree in biotechnology, molecular biology, genomics, biochemistry or related discipline
2. Prefered experience in human or mammalian DNA sequencing, epigenomics, RNAseq, ATAC-seq
3. Priority will be given to candidates with expertise relevant to the TEAM project and in agreement with the general profile of the laboratory. Preliminary work done by applicant in the context of 3D chromatin organization will be treated as the critical for successful candidate.
4. The strong knowledge in bioimaging techniques (3D FISH, chromosome painting etc.) will be the strong asset.
2. Motivation letter (why I would like to join 3DGenomics field?)
3. BSc certificate
4. Short written document about recent advances in 3D genomics
• MSc fellowship 2,500 PLN/month
• Appointment starting 1st May 2019, funding guaranteed for 5 months, possible extension up to 17 months and further beyond TEAM project.
• TEAM project provides unique opportunities for interdisciplinary work between biology, physics, and computer sciences, as well as well established and long-lasting international collaborations with recognized academic institutes and universities in US. Close collaboration with industry will be present as well. We provide also the access to modern 1D and 3D genomics equipment and support from other experienced researchers. International partner (Prof. Yijun Ruan) will be co-supervising your work at the laboratory.
Please submit the following documents to: dr hab. Dariusz Plewczyński, prof. UW
e-mail: firstname.lastname@example.org, tel.: +48 22 55 43654
Laboratory of Functional and Structural Genomics, Center of New Technologies, University of Warsaw
To allow us to process your data, please include the following statement in your application:
“I hereby consent to have my personal data processed by the University of Warsaw with its registered office at ul. KrakowskiePrzedmieście 26/28, 00-927 Warszawa for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the University of Warsaw. I have been informed of my rights and duties. I understand that provision of my personal data is voluntary.”
In accordance with Article 13 of REGULATION (EU) 2016/679 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data – general regulation on data protection (Official Journal of the EU L 119/1 of 4 May 2016) the University of Warsaw informs that:
1. The Controller of your personal data is the University of Warsaw with its registered office at KrakowskiePrzedmieście 26/28, 00-927 Warszawa;
2. The Controller has designated the Data Protection Officer who supervises the processing of personal data, and who can be contacted via the following e-mail address: email@example.com;
3. Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the University of Warsaw;
4. The provided data will be processed pursuant to Article 221 § 1 of the Act of 26 June 1974 Labour Code (uniformed text: Dz.U. of 2018, item 917) and your consent for processing of personal data;
5. Provision of data in the scope stipulated in the Labour Code is mandatory, and the remaining data are processed according to your consent for processing of personal data;
6. The data will not be shared with any external entities;
7. The data will be stored until you withdraw your consent for processing of personal data;
8. You have the right to access your personal data, to rectify, erase them, restrict their processing, object to processing, and to withdraw the consent at any time;
9. You have the right to lodge a complaint to the President of the Office for the Protection of Personal Data.”
Termin nadsyłania aplikacji: 29/04/2019
Słowa kluczowe: chromatin, nucleus, 4D nucleome, chromosomal territories, chromosome painting, Hi-C, 3D genomics