|Project Leader: Prof. Dariusz Plewczyński||Project period: 2019 - 2020|
|Project funding: EDCTP|
Ebolavirus and Marburgvirus (hencefore denoted EBOV and MARV, respectively) are two genera of the negative sense RNA virus family Filoviridae, order mononegavirales. Filoviruses cause rare but fatal viral hemorrhagic fevers-VHF in equatorial Africa–with potential for regional and international urban spread. Both viruses associated VHFs present with a similar prodrome; mimicking several tropical infectious diseases. Early detection is important for mobilizing swift response and control. Existing technologies for filovirus detection are not suited for point of care (POC) use, being expensive, not fast-enough and requiring laboratory facilities absent in many villages where index cases occur. While two rapid diagnostic tests (RDTs) have recently emerged detecting EBOV at the point of care (POC), there are no pan-filovirus targeted RDTs.
Laboratory of Functional and Structural Genomics