Krzysztof Kobielak, M.D., Ph.D.

email: k.kobielak@cent.uw.edu.pl
phone: +48 22 55 43731
room: 02.110
Laboratory of Stem Cells, Tissue Development and Regeneration (Group Leader)

Education and scientific degrees:

1999 – Ph.D. in medical sciences, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, Title of the thesis: “Molecular DNA Research in the Christ-Siemens-Touraine syndrome”. Under the supervision of: Professor Wiesław Henryk Trzeciak

1996 –  M.D., K. Marcinkowski University of Medical Sciences, Poznan, Poland

 

Professional background:

11/2015 – currently Group Leader, Laboratory of Stem Cells, Development and Tissue Regeneration, Centre of New Technologies (CeNT), The University of Warsaw (UW), Warsaw, Poland

 

2007 – 2015                   Assistant Professor, Head of the Laboratory in The Broad Center for Regenerative Medicine & Stem Cell Research, Department of Pathology, Keck School of Medicine, the University of Southern California (USC), Los Angeles, USA

 

2002 – 2007                  Postdoctoral Associate, Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University (RU), New York, USA

 

2000 – 2002                  Postdoctoral Associate, Howard Hughes Medical Institute, Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, Illinois, USA

 

2000 – 2001                   Adjunct, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, Poland

 

1997 – 2000                   Assistant, Department of Biochemistry and Molecular Biology, K. Marcinkowski University of Medical Sciences, Poznan, Poland

 

1995-1997                     Research Assistant, Graduate Student, Department of Biochemistry & Molecular Biology, University of Medical Sciences, Poznan, Poland

 

Honors and Awards

  1. Opienska-Blauth First Prize, best paper presented by a student, 31st Meeting of the Polish Biochemical Society, Warsaw, Poland, 1995

 

  1. Award from President of the Marcinkowski University for the best Ph.D. thesis, Poznan, Poland, 1999

 

  1. FEBS Scholarship for Young Researcher, 26th Meeting of the Federation of European Biochemical Societies, Nice, France, 1999

 

  1. Scholarship for Ph.D. Thesis founded by the State Committee for Scientific Research (KBM) (#4 P05B 063 13) for: Molecular analysis of DNA in Christ-Siemens-Touraine syndrome, 1999-2000

 

  1. FEBS Scholarship for Young Researcher, 18th International Congress of Biochemistry and Molecular Biology, Birmingham, UK, 2000

 

  1. Young Scholar Award, Foundation for Polish Science, Warsaw, Poland, 2000

 

  1. Mozolowski First Prize, best paper presented by a doctoral student, 36th Meeting of the Polish Biochemical Society, Poznan, Poland, 2000

 

  1. Project Leader (#4 P05 A 054 17) granted by the State Committee for Scientific Research (KBN) for: Anhydrotic ectodermal dysplasia as a model for differentiation of skin appendages, 2000-2001

 

  1. Award from Polish Minister of Health for best paper published in 2003, 2004

 

  1. Robert E and May R. Wright Foundation Award, 2009-2010

 

  1. Donald E. and Delia B. Baxter Foundation Award, 2009-2010

 

  1. Robert S. Cleland Excellence in Teaching Award (presented by USC graduate students), 2010-2011

 

Major Areas of Research Interest

Adult Stem Cells

Stem Cells Microenvironment, Stem Cells Niche

Hair Follicle Stem Cells, Hair Regeneration

Nail Proximal Fold Stem Cells, Digit Regeneration

Sweat Gland Stem Cells, Skin Regeneration

 

Research Grants

Current:

TEAM, The Foundation for Polish Science (FNP), K. Kobielak (PI) Reciprocal interaction between hair follicle Stem Cells and surrounding niche during skin and hair regeneration. 2018-2021

OPUS, The National Science Center (NCN), K. Kobielak (PI) Hair follicle stem cells regulation during hair cyclic regeneration. 2016-2019

 

Completed Research Support:

R01, National Institutes of Health (NIH)/NIAMS, USA, K. Kobielak (PI) Activator – Inhibitor interactions in the cyclic regeneration of hair follicle. 2012-2017

 

R03, National Institutes of Health (NIH)/NIAMS, USA, K. Kobielak (PI) Isolation and characterization of new adult stem cells from sweat glands. 2011-2017

 

Baxter Foundation, K. Kobielak (PI) The role of BMP signaling in regulation of hair follicle stem cells. 2009-2010

 

Wright Foundation, K. Kobielak (PI) The role of niche microenvironment in initiation of tumor formation in skin after activation of hair follicle stem cell. 2009-2010

 

Selected publications:

Kobielak K#, Pasolli HA, Alonso L, Polak L, Fuchs E.  Defining BMP function in the hair follicle by conditional ablation of BMP receptor-1A.  J Cell Biol 163:609-623, 2003, article awarded with the journal cover, (U.S. Patent Application No.: US 2012/0034616 A1, Pub. Date: Feb. 9, 2012)

 

Kobielak K#, Stokes N, de la Cruz J, Polak L, Fuchs E.  Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. PNAS 104:10063-10068, 2007

 

Kandyba E, Leung Y, Chen YB, Widelitz R, Chuong CM, Kobielak K.*  Competitive balance of Intrabulge BMP/WNT signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. PNAS 110(4):1351-6, 2013. (Faculty of 1000 Recommendation), (US Patent Application No.:US 2015/0033371 A1, Pub. Date: Jan. 29, 2015)

 

Kandyba E, Hazen V, Kobielak A, Butler J.S, Kobielak K.*  Smad1&5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis towards the postnatal state. Stem Cells. 32(2):534-47, 2014

 

Kandyba E, Kobielak K.*  Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling. Stem Cells. 32(4):886-901, 2014, (Faculty of 1000 Recommendation)

 

Leung Y, Kandyba E, Chen YB, Ruffins S, Chuong CM, Kobielak K.*  Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration. PNAS 111(42):15114-9, 2014

 

Kobielak K.#*, Kandyba E, Leung Y. “Skin and Skin Appendages Regeneration” in Translational Regenerative Medicine, Academic Press, Chapter 22. Editor(s): Atala A, Allickson JG., pages:269-292, 2015, Book’s chapter/invited review article, Elsevier Publications

 

Leung Y, Kandyba E, Chen YB, Ruffins S, Kobielak K.*  Label-Retaining Cells (LRCs) with Myoepithelial characteristic from the Proximal Acinar Region define Stem Cells in Sweat Gland. PLOS ONE. 18;8(9):e74174, 2013

 

Kobielak K.* Nail. Fitzpatrick’s Dermatology in General Medicine, 9th Edition. McGraw-Hill Education, New York, Chapter 8:106-115, ISBN-13: 978-0071837798, Editor(s): Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer J. Book’s chapter invited. 2019

 

# first author;  * corresponding author

 

Patents:

Fuchs E, Jamora C, Kaufman C and Kobielak K

Methods for modulating epithelial stem cell lineage

U.S. Patent Application No. 12/894,720, filed Sep.30, 2010 (Pub. No.: US 2012/0034616 A1, Pub. Date: Feb. 9, 2012)

 

Kobielak K and Kandyba E

Hair Follicle Stem Cells and Methods of Use.  U.S. Patent Application No.61/534 828 & 61/539 936 filed September 14&27, 2011 (Pub. No.: US 2015/0033371 A1, Pub. Date: Jan. 29, 2015)

 

Kobielak K

Sweat Gland-Derived Stem Cells and Methods of Use.  US Patent Application No. 61/051,422, filed September 17, 2014 (Pub. No.: US 2016/0075995 A1, Pub. Date: Mar. 17, 2016)

 

Membership in International and National Scientific Societies

 

The Society for Investigative Dermatology, 2009-present

The International Society for Stem Cell Research (ISSCR), 2009-present

North American Hair Research Society (NAHRS), 2013-present

The American Society for Cell Biology, 2008-present

The American Association for Cancer Research, 2009-2014

New York Academy of Science, 2002-2006

Polish Biochemical Society, 1997-2000

Polish Society of Human Genetics, 1997-2000