Unveiling fundamental biological processes in adult stem cells regulation is important, since stem cells are not only required for physiological tissue or organ self-renewal but also play critical role during their regeneration after injury. Therefore understanding a precise regulation of adult stem cells homeostasis is very crucial since deregulation of stem cells self-renewal might result in organ failure or tumor formation. Thus, further discovery of the molecular factors tightly governing intrinsic balance of signaling pathways in stem cells is very important question in regenerative medicine and one of the goals of my laboratory. This knowledge might be very essential to understand a common mechanism of stem cells homeostasis and tissue regeneration and might be useful to adopt these basic discoveries to novel form of stem cell therapies in human. To address it, my laboratory will use independent skin stem cells from hair, sweat glands and nails as a model to decipher their molecular mechanism of regulation and their properties during skin, hair and limb/digit regeneration. Dissecting the underlying similarities and differences which occur during distinct skin appendages renewal may prove highly beneficial in unraveling the fundamental principles which govern tissue or organ regeneration in vivo.
phone: +48 22 55 43731
Krzysztof Kobielak, M.D., Ph.D.
Łukasz Boryń, PhD
Tomasz Pieczonka, PhD
Anna Karolina Płatek, PhD
Patrycja Daszczuk, MSc
Paula Mazurek, MSc
Alicja Olczak, MSc
Agnieszka Kikulska, PhD Eng.
|Title||Project Leader||Project period||Project funding|
|Regulators of BMP and WNT signaling pathways in homeostasis of hair follicle stem cells||Patrycja Daszczuk||2018 - 2021||PRELUDIUM, NCN|
|Reciprocal interaction between hair follicle Stem Cells and surrounding niche during skin and hair regeneration||Krzysztof Kobielak||2018 - 2020||TEAM, FNP|
|Hair follicle stem cells regulation during hair cyclic regeneration.||Krzysztof Kobielak||2016 - 2019||OPUS, NCN|
Szyndler, J., Maciejak, P., Kołosowska, K., Chmielewska, N., Skórzewska, A., Daszczuk, P., & Płaźnik, A. (2018).
Pharmacological Reports, 70(1), 14-21.
Wang, X., Wang, G., Ramos, R., Wang, X., Daszczuk, P., Mazurek, P., . . . & Kobielak, K.
Journal of Investigative Dermatology, 138(5)
Lee, P., Gund, R., Dutta, A., Pincha, N., Rana, I., Ghosh, S., Witherden, D.. Kandyba, E., MacLeod, A., Kobielak, K. M., Havran, W. L. (2017).
Elife, 6, e28875.
Wang, Q., Oh, J. W., Lee, H. L., Dhar, A., Peng, T., Ramos, R., ... & Le, J. (2017).
Hughes, M. W., Jiang, T. X., Lin, S. J., Leung, Y., Kobielak, K., Widelitz, R. B., & Chuong, C. M. (2014).
Journal of Investigative Dermatology, 134(1), 24-32.
Kandyba, E., Hazen, V. M., Kobielak, A., Butler, S. J., & Kobielak, K. (2014).
Stem cells, 32(2), 534-547.
Kandyba, E., Leung, Y., Chen, Y. B., Widelitz, R., Chuong, C. M., & Kobielak, K. (2013).
Proceedings of the National Academy of Sciences, 110(4), 1351-1356.
Leung, Y., Kandyba, E., Chen, Y. B., Ruffins, S., & Kobielak, K. (2013).
PloS one, 8(9), e74174.
|Title||Deadline for applications|
|PhD student to work in the Laboratory of Stem Cells, Tissue Development and Regeneration||21/01/2019|
|Postdoc in the Laboratory of Stem Cells, Tissue Development and Regeneration||15/07/2018|