Laboratory of Stem Cells, Tissue Development and Regeneration

Unveiling fundamental biological processes in adult stem cells regulation is important, since stem cells are not only required for physiological tissue or organ self-renewal but also play critical role during their regeneration after injury. Therefore understanding a precise regulation of adult stem cells homeostasis is very crucial since deregulation of stem cells self-renewal might result in organ failure or tumor formation. Thus, further discovery of the molecular factors tightly governing intrinsic balance of signaling pathways in stem cells is very important question in regenerative medicine and one of the goals of my laboratory. This knowledge might be very essential to understand a common mechanism of stem cells homeostasis and tissue regeneration and might be useful to adopt these basic discoveries to novel form of stem cell therapies in human. To address it, my laboratory will use independent skin stem cells from hair, sweat glands and nails as a model to decipher their molecular mechanism of regulation and their properties during skin, hair and limb/digit regeneration. Dissecting the underlying similarities and differences which occur during distinct skin appendages renewal may prove highly beneficial in unraveling the fundamental principles which govern tissue or organ regeneration in vivo.

Krzysztof Kobielak, M.D., Ph.D.
phone: +48 22 55 43731
room: 02.110

Altered expression of GABA-A receptor subunits in the hippocampus of PTZ-kindled rats
Szyndler, J., Maciejak, P., Kołosowska, K., Chmielewska, N., Skórzewska, A., Daszczuk, P., & Płaźnik, A. (2018).
Pharmacological Reports, 70(1), 14-21.
1392 Activation of Id2 gene regulatory network ruling quiescence of hair follicle stem cells
Wang, X., Wang, G., Ramos, R., Wang, X., Daszczuk, P., Mazurek, P., . . . & Kobielak, K.
Journal of Investigative Dermatology, 138(5)
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells
Lee, P., Gund, R., Dutta, A., Pincha, N., Rana, I., Ghosh, S., Witherden, D.. Kandyba, E., MacLeod, A., Kobielak, K. M., Havran, W. L. (2017).
Elife, 6, e28875.
A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning
Wang, Q., Oh, J. W., Lee, H. L., Dhar, A., Peng, T., Ramos, R., ... & Le, J. (2017).
Elife, 6.
Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis.
Hughes, M. W., Jiang, T. X., Lin, S. J., Leung, Y., Kobielak, K., Widelitz, R. B., & Chuong, C. M. (2014).
Journal of Investigative Dermatology, 134(1), 24-32.
Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation.
Kandyba, E., Leung, Y., Chen, Y. B., Widelitz, R., Chuong, C. M., & Kobielak, K. (2013).
Proceedings of the National Academy of Sciences, 110(4), 1351-1356.
Label retaining cells (LRCs) with myoepithelial characteristic from the proximal acinar region define stem cells in the sweat gland.
Leung, Y., Kandyba, E., Chen, Y. B., Ruffins, S., & Kobielak, K. (2013).
PloS one, 8(9), e74174.