Results of the competition:
As part of the conducted procedure, the Competition Committee recommended the candidacy of Piotr Surynt, MSc for the post of PhD student.
We seek motivated candidates with a MSc degree in (bioorganic) chemistry or related field, fluent English and a strong interest in chemistry of nucleotides and oligonucleotides. The successful candidate should have experience in organic synthesis and bioorganic/medicinal chemistry, knowledge of methods for compound purification and spectroscopic characterization. Skills in enzymatic assays, studying protein-ligand interaction by biophysical methods, and experience in biochemistry will also be appreciated.
The position will involve design, synthesis and studying properties of novel nucleotide analogs and development of new synthetic methods for the preparation of nucleotide analogs. The project will involve synthesis of molecular rotors, TMG cap analogues modified with molecular rotors, TMG capped oligonucleotide conjugates, and studies on degradation and interactions with proteins.
Description of the position
Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies.
The trimethyl cap structure (TMG cap), which is located at the 5’end of snRNA serves as a nuclear localization signal (NLS). This signal is recognized by adaptor protein snurportin1, which together with the importin β, transport TMG capped snRNA to the nucleus. This nuclear transport may be used to deliver therapeutic oligonucleotides or other biologically important molecules to the nucleus. The aim of the project is the synthesis of TMG cap analogs, which will provide tools for the study of nuclear transport. Therefore, we plan to synthesize TMG cap analogs labeled with molecular rotors
How to apply?
– CV including a description of prior research experience
– cover letter
– a transcript of record from undergraduate studies
– contact details (phone numbers and e-mails) for the persons that can provide recommendations
– a list of publications and conference presentations
Applications should be submitted by e-mail to Błażej Wojtczak and Jacek Jemielity (firstname.lastname@example.org, email@example.com,) no later than 31st of October 2018 at 12:00 (GMT+1) with the term “Ph. D. student position SONATA” as email’s topic.
Following an initial screening of the applications, selected candidates will be contacted by e-mail for further recruitment steps. after successful recruitment, the candidate will have to obtain the status of PhD student at the Faculty of Chemistry of the University of Warsaw.
The offers will be accepted until the laureate is announced. In the case of not signing the contract by the candidate, due to the resignation, we reserve the rights to choose the next candidate from the ranking list. We reserve the rights to invite the selected candidates only.
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Tags: trimethyl cap analogs, TMG cap, molecular rotors, nucleotide synthesis, cap binding proteins, nuclear transport