The Centre of New Technologies invites to a seminar by
Prof. Peter O’Hare
Imperial College London
Bio-orthogonal Chemistry and Proteomics:
A Revolution for Virology, Immune Sensing and Vaccine Development
Date: April 26th, 2019 at 12:00 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Remigiusz Serwa, PhD
Abstract:
The O’Hare laboratory investigates infection by the class of large DNA viruses, the herpesviruses, which cause a range of clinically important diseases, especially in immunocompromised individuals.
We focus on the earliest events during initiation of infection including capsid transport, genome nuclear import, the host transcriptional apparatus, repressive virus-host interactions and the modulation of the protein translational machinery and intercellular protein trafficking.
Considerable insight into these events has come from population studies at the protein, DNA or transcript level. However it is becoming clear we must also understand processes at the single cell level and how these integrate across populations. This raises major challenges and until recently many of these questions have not been tractable due to technical limitations.
We aim to exploit new opportunities in bioorthogonal chemical biology and systems proteomics, integrating population based and single cell based analysis to address key questions on virus infection biology. The seminar will expand on these opportunities that are beginning to yield transformative insights into virus infection at the single cell, and single molecule levels, while at the same time offering completely new opportunities in translational application such as in the field of viral vaccines.
