The Centre of New Technologies invites to a webinar by
Anna Malik, PhD
Nencki Institute of Experimental Biology, Warsaw
Title: New players in glia biology: VPS10P proteins as sorting receptors in astrocytes.
Date: 22th May 2020 (Friday)
Time: 12:00 pm
Virtual seminar: here
Password: cent (the password will be filled in automatically)
Host: Dr Savani Anbalagan
VPS10P domain receptors – How to sort out brain health and disease
VPS10P domain receptors are intracellular sorting receptors primarily recognized for their roles in neuronal cells. They direct cargo proteins to their destined localization in subcellular compartments of the cell. Sorted proteins include signaling receptors and transporters but also secreted growth factors and morphogens. Protein sorting by VPS10P domain receptors controls functional integrity and viability of neurons, while receptor dysfunctions are linked to acute, psychiatric, and neurodegenerative diseases. Now, the dogma of exclusive neuronal expression of VPS10P receptors in the brain was challenged by several studies, drawing our attention to receptor activities in non-neuronal cell types, i.e. astrocytes and microglia, in pathologies of central nervous system. Here, I will present major concepts in VPS10P research, but I will also focus on the newest advancements regarding non-neuronal functions of VPS10P receptors in the brain.