The enzyme Dcp2 alongside with its activator (Dcp1) and set of coactivators (Edc1 and Edc2) create a complex, that recognizes and removes the 5′ eucaryotic cap from mRNA transcripts. Cap removal is a critical step of many cellular RNA decay pathways, hence its functioning is highly desired to be known and well-described.
In their article, Jacek Jemielity and Marcin Ziemniak from the Laboratory of Bioogranic Chemistry in collaboration with John Gross from UCSF, San Francisco, USA, explain the mechanism of cap recognition and maintaining the active conformation of the enzyme throughout the decapping process.
We encourage you to read the article published in “Nature Communications”.
